Chlorpromazine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸氯丙嗪是一种多巴胺和钾通道抑制剂，用作典型的吩噻嗪抗精神病化合物。

Chlorpromazine hydrochloride is a dopamine and potassium channel inhibitor used as the prototypical phenothiazine antipsychotic drug.

Cell Proliferation Assay Cell Line:U-87MG glioma cells Concentration:0, 10, 20, 40 μM Incubation Time:0, 24, 48 hResult:Showed anti-proliferative activity in a dose- and time-dependent manner.Immunofluorescence Cell Line:Bone marrow cells (sEV-treated) Concentration:10 μM Incubation Time:1 h Result:Reduced MDSCs and suppressed the sEV internalization.Western Blot Analysis Cell Line:U-87MG glioma cells Concentration:20 μM Incubation Time:0, 12, 24, 48 h Result:Decreased the levels of cyclin A and cyclin B1 12 h later, whereas levels of cyclin D1, proliferating cell nuclear antigen and GAPDH remained unchanged.

Animal Model:5- to 6-week-old athymic nude mice bearing intracranial U-87MG xenograft tumors.Dosage:20 mg/kg Administration:Injected intraperitoneally; single daily for 7 days Result:Inhibited tumor growth on day 17.

CPZ

Endocrinology/Hormones

5-HT Receptor

5-HT2A| D2

Neurological Disease

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69-09-0

355.32

C17H19ClN2S·HCl

>98% (HPLC)

Ethanol: 71 mg/mL (199.81 mM); Water: 71 mg/mL (199.81 mM); DMSO: 71 mg/mL (199.81 mM)

Cl.CN(C)CCCN1C2=CC=CC=C2SC2=C1C=C(Cl)C=C2

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(-20℃)

With Ice Pack

≥ 2 years